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Apoaequorin: The Overview
Apoaequorin is a main substance that is included in a popular memory supplement called Prevagen. This key ingredient is a protein derived from a certain type of Jellyfish and was found to have some benefits for cognitive decline in seniors, although it is said to help younger people too. It is included in this widely advertised supplement which made to support several aspects of cognitive function. For most people, symptoms of cognitive decline such as poor memory, difficulty in concentrating, inability to process information occur with age although they can also be caused by stress and certain health conditions.

As previously mentioned, this protein is derived from the bio-luminescent Jellyfish, is said to help regulate calcium levels in humans and it is this function that affects the cognitive state – by maintaining low levels of cytosolic calcium the performance of the neurons is less likely to be compromised as the brain ages. In turn, this means that the person taking the substance may enjoy better memory and information retention safely and with no risk of side effects. It can also be used by anyone with a seafood allergy, although it is advised that a doctor is consulted first.
Good About This Supplement
- It may help regulate calcium levels
- It is a natural substance
- Support several aspects of cognitive function
Bad About This Supplement
- Clinical trial studies are not cited
- It is not as well known as other nootropic ingredients
- There is some controversy about its use
The Bottom Line
While some people consider this main ingredient for supporting cognitive decline, there still seems to be some unknown results about its ability as a nootropic, especially when there are other more well known substances, such as Extracts of Vinca Minor, Bacopa and Phosphatidyserine, present on the market and usually included in top cognitive health supplements.
The company contends the product is safe and “hundreds of thousands people tell us it works and improves their lives”. It can cost up to $69 per bottle, is sold at major retailers and pharmacies across the country, including CVS, Walgreens, Rite-Aid, the Vitamin Shoppe, and Amazon.
In addition to having numerous reviews from people who have used this supplement, it has not performed well in clinical testing and should not produce results in the time stated when taken as directed. We think there are better options which would require a little bit more research but you would be getting more overall benefits.